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Monitor levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), a metabolite of norepinephrine. Patients with either high or low levels of MHPG have demonstrated marked sleep disturbance, which may be related to unipolar depression.1
1. Samson JA, Mirin SM, Griffin M, Borrelli D, Schildkraut JJ. Urinary MHPG and clinical symptoms in patients with unipolar depression. Psychiatry Res. 1994 Feb; 51(2):157-165. PubMed 8022950
